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Hyaluronan hybrid cooperative complexes

Hyaluronan hybrid cooperative complexes as a novel frontier for cellular bioprocesses reactivation

Hyaluronan hybrid cooperative complexes as a novel frontier for cellular bioprocesses reactivation

[…] In this study, the multi-faceted interaction between keratinocytes and dermal fibroblasts in presence of the novel hybrid cooperative complexes HA formulation was evaluated. The in vitro model employed, has made possible the functional interaction between the two cell types, involving the synthesis and assembly of the skin ECM proteins. The results showed a notably different biological response, regarding collagen and elastin expression and synthesis, of HA hybrid cooperative complexes respect
to native HA formulations. A key feature of the hybrid cooperative complexes was the prolonged stability to enzymatic attack, despite the absence of chemical cross linking. These findings could overall corroborate the in vivo clinical data obtained on the HA
hybrid cooperative complex38. […]