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        Efficacy and tolerance of an injectable medical device

        Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high and low molecular weight hyaluronic acid: a monocentric 16 weeks open-label evaluation

        […] The results of this explorative prospective study, evaluating the clinical efficacy and tolerability, clearly supports the bio-remodeling and rejuvenation claim of the hybrid cooperative complexes. All subjective clinical outcomes and the majority of objective instrumental results indicate a rapid and statistically significant improvement in the face attractiveness parameters. In particular, the volumetric and tightening effects were significant and maintained until the end of the study. From week 8, filling, antiwrinkle, plumping, and hydrating activities become statistically significant, as measured by the reduction of WSRS score, profilometric, torsiometric, and skin electrical capacitance parameters. These instrumental and clinical findings are also confirmed by the photographic documentation. […]

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