The effects on wound healing

[…] In this study, low molecular weight HA (L-HA) proved not to be toxic/inflammatory, and therefore permitted wound closure similarly to the well-known bioactive high molecular weight HA (H-HA). Novel hybrid complexes formed by H-HA and L-HA performed better than HA alone, both at high or low concentrations. Complexes also showed better stability of long chains HA to hyaluronidases attack, presumably prolonging their half-lives in vivo. L-HA accelerates wound repair at an earlier stage, while H-HA has no short-term effect, probably due to its initial higher viscosity. The outcomes of this study may be the pillars for further in vivo studies to promote HA hybrid complex use in innovative medical devices for tissue regeneration. […]